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Why was there the initial concept of “supplementing NAD+for life extension”?

Nad+ life extension nad cell regenerator

What is NAD+ life extension nad cell regenerator?

NAD+, full name nicotinamide adenine dinucleotide. It always called life extension nad cell regenerator, is an important coenzyme in the human body. NAD+ exist in almost every cell of the body and participate in various physiological activities such as energy metabolism and DNA repair. As we all know, with age, the level of NAD+in our body gradually decreases. Dr. Attia pointed out that NAD+levels in the blood decreased by 10% to 20% over a period of about 40 years.

 

Nad+ life extension nad cell regenerator

From this perspective, ‘supplementing NAD+can life extension’ seems reasonable. However, Dr. Atiyah put forward another viewpoint, believing that although NAD+levels continue to decrease during the aging process, supplementing NAD+does have certain benefits, there is currently no research to prove that this can life extension, and exceeding a certain level will be fatal! He mentioned that 99% of NAD+is used as an electron transporter, which means it is not consumed but acts as an electron transporter. Only a small portion of NAD+is consumed by the longevity gene Sirtuins to repair DNA. Moreover, the NAD+levels within cells are strictly controlled, just as glucose is regulated by the body’s insulin and adrenaline. As an organism, we cannot survive outside a certain pH range. On a scale of 0-14, if NAD+levels are below 7 or above 7.8, we will die.

The benefits of NAD+

Regarding the claim that “NAD+supplements can have anti-inflammatory effects.”  Dr. Huberman stated that he believes NAD+has anti-inflammatory properties, which is why he has been taking NMN. However, Dr. Atiyah conducted official anti-counterfeiting and mentioned two studies: one was a study on the effect of NR on fatty liver, in which 100 people with fatty liver were treated with half the regular dose of NR and half the double dose. The results showed no differences in fat content, inflammatory markers, weight, blood sugar, etc. between the two groups. But if the liver fat content of the experimental subjects is initially below 27%, after taking low-dose NR, the fat content decreases from 20% to 15%.

Another study is about the effect of NMN on the body’s glucose processing ability. Two groups of experimental subjects, with and without insulin injection, showed a slight increase in glucose processing capacity in the NMN group after insulin treatment. The results of these two studies can be said to be statistically significant, but do they have significant implications for the patient population? It’s equivalent to giving a diabetic a drug that can reduce his blood sugar by several milligrams. It’s actually useless.

Did all the NAD+supplements I spent a lot of money on before go to waste?

Although the two professors have questioned individual claims about NAD+supplements, they have also shared some benefits of supplementing NAD+. Take Dr. Huberman as an example, he has actually been taking NMN himself, whether it is pills or intravenous infusion. For me, the most obvious effect is that it makes my hair grow faster, my nails grow faster, and I feel more energetic. I usually eat it first thing in the morning. ” Professor Atiyah added, adding that supplementing NAD+can also reduce the risk of skin cancer. “One study showed that after taking NMN or NR, the incidence rate of basal cell carcinoma and squamous cell carcinoma was reduced by 60% -80%. These two types of cell carcinoma are quite common and related to prolonged exposure to the sun.”

Why does it reduce the risk of skin cancer? Dr. Atiyah speculates that this may be related to the degree of decrease in NAD+levels in the skin. Among all tissues, the skin has the fastest decline in NAD+levels. Seeing this, Pai Pai breathed a sigh of relief. Although NAD+supplements are not so-called “anti depressants”, they are still beneficial to health, but they cannot be blindly supplemented. That’s why it’s important to undergo professional testing and choose a scientifically reasonable dosage before taking supplements.

How to use NAD+

NAD+generally requires injection supplementation, with common specifications including NAD+500mg, 300mg, and 250mg. More NAD+ effects and dosage can be discussed on the Reddit Peptide Forum.

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