NMN has positive impact on ovarian function
On September 30, 2024, the international academic journal MedComm published a significant new research achievement. This study was jointly conducted by Professor Chen Rong’s team and Professor Zhang Peng’s team. Professor Chen Rong from Peking Union Medical College Hospital, Chinese Academy of Medical Sciences. Professor Zhang Peng’s team from National Children’s Medical Center/Beijing Children’s Hospital Affiliated to Capital Medical University. They conducted in-depth research on the positive effects of NMN on ovarian function in elderly mice and elucidated its possible mechanisms of action. This provide new scientific evidence for understanding the potential applications of NMN in the field of reproductive health.
NMN improves ovarian hormone secretion
The research results showed that supplementing NMN significantly increased estrogen levels in the serum of elderly mice. It can reduce follicle stimulating hormone levels, and increased anti Mullerian hormone levels, indicating that NMN improved ovarian hormone secretion. In addition, NMN also reduced oxidative stress markers in serum and inhibited the increase in inflammation caused by aging. It reduce the concentration of pro-inflammatory factors in serum.
The study further observed the effects of NMN on lipid droplets and mitochondria in ovarian granulosa cells through scanning electron microscopy. The results showed that as age increased, the lipid droplet density and average area in granulosa cells decreased, while NMN significantly increased the lipid droplet content and average area in granulosa cells during late developmental stages. In addition, NMN significantly improved the ultrastructure of mitochondria in granulosa cells. It increase the ratio of mitochondrial cristae to mitochondrial area and reduce the distance between cristae within mitochondria, indicating that NMN treatment significantly altered the ultrastructure of mitochondria in granulosa cells, which had a positive impact on follicle development and maturation.
NMN regulates aging genes to alleviate ovarian inflammation
To explore how NMN supplements exert anti-aging effects, researchers conducted transcriptome analysis on ovarian tissues of young, aged, and aged+NMN treated mice. The results showed that compared with the young group, the elderly group had 2757 genes upregulated and 2691 genes downregulated. Compared with the elderly group, the elderly+NMN group showed 1173 upregulated genes and 995 downregulated genes. In addition, compared with the younger group, the expression of genes related to immune and inflammatory cell pathways increased in the ovarian tissue of the aging group, while supplementing with NMN upregulated the expression of genes related to energy metabolism pathways and downregulated the expression of genes related to inflammation and immune pathways. Indicating that NMN can alleviate the inflammatory response in ovarian tissue of aging mice. It regulate processes such as cell adhesion, migration, and extracellular matrix remodeling.
NMN reverses ovarian atrophy
The study also validated the effects of NMN on ovarian health, including ovarian atrophy, fibrosis, lipid accumulation, cell apoptosis, and expression of aging markers. The results showed that NMN effectively reversed ovarian atrophy in elderly mice, reduced fibrotic areas, improved lipid droplet distribution, inhibited cell apoptosis, and reduced the expression of aging markers.
Overall, NMN improves the health status of aging ovaries by enhancing mitochondrial function. It improving energy metabolism, regulating aging gene expression, reducing ovarian inflammation levels. These findings provide new insights into improving the fertility of elderly women. It obtaining more high-quality oocytes for assisted reproductive technologies. But these findings still need to be validated in larger populations. Further clinical studies are needed to determine the safety and efficacy of NMN.
About NMN
NMN (β – nicotinamide mononucleotide) is a precursor substance of NAD+, which can be directly converted into NAD+to exert its effects.
