Tirzepatide for weight loss you need to know - Tirzepatide user guide
What is tirzepatide?
Tizepamide is a linearly synthesized peptide containing 39 amino acids partially conjugated with C20 fatty acids. Its protein sequence is based on endogenous GIP sequences, and its pharmacological effects on GLP-1 receptors are equivalent to endogenous GIP; However, the half-life of Tizepamide is relatively long and weekly administration is allowed. Texaparide was approved by FDA on May 13, 2022, with the trade name of MOUNTJARO, for the treatment of adult type 2 diabetes, making it the first and only GIP and GLP-1 receptor agonist for this indication. Later, on November 8, 2023, it was approved under a different brand name ZEPBOUND for long-term weight management in adults with at least one type of weight related obesity or overweight. On September 15, 2022, ticalopatide was also approved by the European Commission. On May 21, 2024, Tirzepatide was approved by the China National Medical Products Administration for the treatment of adult type 2 diabetes,with the brand name MOUNTJARO.
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are hormones involved in blood-sugar control. After a person has eaten, these hormones are secreted by cells of the intestines, and in turn cause the secretion of insulin. Tirzepatide is a long-acting GIP-analogue that activates both the GLP-1 and GIP receptors, leading to improved blood-sugar control.
Tirzepatide, sold under the brand names Mounjaro and Zepbound, used for the treatment of type 2 diabetes and for weight loss.
How does tirzepatide works?
Tirzepatide is a dual GIP and GLP-1 receptor agonist, It acts on the glucose-dependent insulinotropic polypeptide (GIP) receptor agonist and the glucagon-like peptide 1 (GLP-1) receptor agonist.
Glucagon like peptide 1 is a receptor agonist targeted by other weight loss and diabetes drugs (such as Wegovy).
However, the reason why Tirzepatide stands out is that it is the first combination of two types of drugs, GIP and GLP-1 receptor agonists, both of which are gut type lowering hormones that are released after food intake.
Tirzepatide works by mimicking these two receptor agonists, including warning the pancreas to stop releasing insulin after eating and sending signals to the liver to lower glucose levels.
Conversely, this can not only help you become fuller, but also slow down digestion and aid in blood sugar control, both leading to weight loss and weight management.
Tirzepatide for weight loss
Tirzepatide helps with weight loss by mimicking the effects of natural hormones that regulate appetite and food intake. It targets the regions of the brain involved in appetite regulation, thereby reducing hunger and enhancing satiety. This can reduce calorie intake and significantly reduce weight. In addition, ticalopatide slows down gastric emptying and helps with longer periods of satiety.
Clinical trials have shown that Tirzepatide is also helpful in helping type 2 diabetes and obesity patients with weight and weight management. A clinical trial involving over 2500 obese or overweight individuals was divided into two treatment groups: those taking Tirzepatide and those taking a placebo. Clinical trials have shown that people who take Tirzepatide lose 15-20% of their body weight within 72 weeks. On the other hand, those in the placebo clinical trial group only showed an average weight loss of 3%.
Who can use tirzepatide
Type 2 diabetes, high cholesterol levels,hypertension and obese adults (BMI ≥ 30kg/m2) or overweight (BMI ≥ 27kg/m2) can use tirzepatide.
According to its body mass index (BMI) and certain health conditions, tirzepatide was approved for weight loss in adults and children aged 12 and above.
Tirzepatide has also been approved to help protect the heart and reduce the risk of heart attack, stroke or heart related death in adults with type 2 diabetes and heart disease.
Can I buy tirzepatide online?
Yes. You can buy tirzepatide online.We have opened an peptides online shopping mall where you can purchase directly.
Benefits, Side effects of Tirzepatide
5 Benefits Of Tirzepatide
1.Improve metabolic health. Tirzepatide can reduce the risk of developing type 2 diabetes by reduceing inflammation and cholesterol levels.
2. Lose weight.
3.Easy to use. The half -life of Tirzepatide is about 1 week. The duration is long, and it only needs to be injected once a week to stabilize blood sugar and continue to lose weight.
4.Well-tolerated. Most people who take tirzepatide experience minimal side effects.
5.Cost -effective. Low dosage, long cycle, easy to buy, can buy it online.
Side effects of Tirzepatide
The side effects of semaglutide are usually mild.
People who take tirzepatide may experience:
dizziness
fatigue
Diarrhea, constipation, and odor
Nausea, vomiting
You may be able to reduce side effects by starting at lower doses and gradually increasing your dosage.
When to inject tirzepatide
Tirzepatide usually injected once a week anytime of the day, with or without diet. You can change the day of the week when tirzepatide is used, as long as you have been using it for 3 days or longer (72 hours or longer) since the last dose.
Tirzepatide dosage for weight loss
Tirzepatide starting from a low dose, the initial dose is 2.5 mg, increase to 5mg after 4 to 20 weeks until reaching target maintenance dose (5mg,10mg or 15mg per week). The maintenance dose based on the toleratance. If you cannot tolerate a 15 mg dose, you may be instructed to inject a maintenance dose of 5 or 10 mg per week.
This Tirzepatide administration schedule is designed to help manage potential side effects. If you cannot tolerate tirzepatide, your prescriber may reduce the dosage or stop taking it.
Tirzepatide dosage chart
|
Time |
Dosage |
|---|---|
|
Week 1 to week 4 |
2.5 mg |
|
Week 5 to week 8 |
5 mg |
|
Following |
Increase 2.5 every 4 to 20 weeks |
Tirzepatide oral vs injection
Tirzepatide is administered By subcutaneous injection. It is not yet available in an oral form.
Tirzepatide vs Semaglutide
Tirzepatide and semaglutide are drugs to treat type 2 diabetes people and help people lose weight. Tirzepatide marketed as the brand name Mounjaro or Zepbound, Semaglutide sold as brand name Ozempic, Rybelsus or Wegovy.
The different between tirzepatide and semaglutide
Tirzepatide is a dual-acting glucagon-like peptide-1 (GLP-1) receptor agonist and glucose-dependent insulinotropic polypeptide (GIP) and binds to both GLP-1 receptors and GIP.
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist and mimics the natural GLP-1 hormone in our bodies.
Tirzepatide combines synthetic mimetics of two hormones, GLP-1 and GIP, and after consumption, the gut naturally releases these two hormones, making people feel full.
Semaglutide reduced weight by at least 20% in one-third of obese individuals.
More than half of obese individuals with Tirzepatide lost at least 20% of their weight.
Both tirzepatide and semaglutide are inject weekly, but dose is different. Tirzepatide dosage is 5mg,10mg or 15mg with initial dose 2.5mg. Semaglutide dosage is 2.4mg with initial dose 0.25mg.
