Semaglutide for weight loss you need to know - semaglutide user guide
What is semaglutide?
Semaglutide belongs to a class of drugs known as GLP-1 RAs (glucagon-like peptide-1 receptor agonists). It simulates GLP-1 hormone, which is released in the intestine in response to diet.
One of the functions of GLP-1 is to promote the production of more insulin in the human body, thereby reducing blood sugar (glucose). As a result, health care providers have used more than 15 years to treat type 2 diabetes.
However, the content of GLP-1 is high and it also interacts with various parts of the brain, which suppress your appetite and send signals to make you feel full. When used in combination with diet and exercise, it may cause obese or overweight people to lose weight and reduce the risk of cancer, diabetes and heart disease.
How does semaglutide works
Semaglutide is GLP-1 analogues, originally approved for the treatment of type 2 diabetes, have received a lot of publicity in the past few years, largely because of their ability to help people lose weight.
So far, the understanding of GLP-1 analogues is through mimicking the action of molecules with similar shapes, called glucagon like peptides, which are naturally released from the intestine shortly after food.
This peptide is associated with the pancreas β Specific receptors on the cell surface bind, causing them to release insulin. For a long time, researchers believe that GLP-1 analogues only affect insulin release, so why are they prescribed for type 2 diabetes.
The effect of these drugs on weight has not attracted people's attention, because weight loss can help people with type 2 diabetes better control blood sugar, or even alleviate the disease.
Recent studies have found that the working mode of GLP-1 analogues helps to reduce weight, including slowing down gastric emptying and enhancing a person's sense of fullness after eating.
Semaglutide for weight loss
Semaglutide plays a role in appetite and digestion. People believe that there are several different ways to help you lose weight. These include:
- Slow down food from the stomach (gastric emptying)
- Targeting brain regions helps regulate appetite and satiety
- Reduce craving for certain foods, such as salty snacks or candies
Over time, certain semi Lupin effects (such as slowed gastric emptying) may decrease. Other Semaglutide effects, such as reducing appetite, only have the effect of using medication.
Without changes in lifestyle, 2.4 milligrams of subcutaneous semaglutide per week resulted in an average weight loss of 10% to 15% (10 to 15 kg) within 68 weeks.
Who can use semaglutide
Type 2 diabetes, high cholesterol levels,hypertension and obese adults (BMI ≥ 30kg/m2) or overweight (BMI ≥ 27kg/m2) can use semaglutide.
Semaglutide was approved for medical use in the US in 2017to treat type 2 diabetes.
According to its body mass index (BMI) and certain health conditions, semaglutide was approved for weight loss in adults and children aged 12 and above.
Semaglutide has also been approved to help protect the heart and reduce the risk of heart attack, stroke or heart related death in adults with type 2 diabetes and heart disease.
Can I buy semaglutide online?
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Benefits, Side effects of Semaglutide
5 Benefits Of Semaglutide
1.Improve metabolic health. semaglutide can reduce the risk of developing type 2 diabetes by reduceing inflammation and cholesterol levels.
2. Lose weight safely
3.Easy to use. The half -life of Semaglutide is about 1 week. The duration is long, and it only needs to be injected once a week to stabilize blood sugar and continue to lose weight.
4.Well-tolerated. Most people who take semaglutide experience minimal side effects.
5.Cost -effective. Low dosage, long cycle, easy to buy, can buy semaglutide online.
Side effects of semaglutide
The side effects of semaglutide are usually mild.
People who take semaglutide may experience:
dizziness
fatigue
Diarrhea, constipation, and odor
Nausea, vomiting
You may be able to reduce side effects by starting at lower doses and gradually increasing your dosage.
When to inject semaglutide
It usually injected once a week with or without diet. It injections at any time of the day every week. You can change the day of the week when semaglutide is used, as long as you have been using it for 2 days or longer (48 hours or longer) since the last dose.
Semaglutide dosage for weight loss
Semaglutide usually starting from a low dose, the initial dose is 0.25 mg, increasing 0.25mg or 0.5mg every 4 weeks until reaching 2.4 milligrams per week (target maintenance dose). However, if you cannot tolerate a 2.4 mg dose, you may be instructed to inject a maintenance dose of 1.7 mg per week.
This Semaglutide administration schedule is designed to help manage potential side effects. If you cannot tolerate Semaglutide, your prescriber may reduce the dosage or stop taking it.
Semaglutide dosage chart
|
Time |
Dosage |
|---|---|
|
Week 1 to week 2 |
0.25 mg |
|
Week 3 to week 4 |
0.5 mg |
|
Following |
Increase 0.25 every 2 weeks |
Semaglutide oral vs injection
In 2021 and 2023, FDA approved oral semaglutide for the treatment of obesity and adolescent obesity. It is currently one of the few drugs officially approved by the FDA for the treatment of obesity in the world.
Semaglutide vs Tirzepatide
Semaglutide and Tirzepatide are drugs to treat type 2 diabetes andweight loss. Semaglutide sold as brand name Ozempic, Rybelsus or Wegovy. Tirzepatide marketed as the brand name Mounjaro or Zepbound.
The different between semaglutide and tirzepatide
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist and mimics the natural GLP-1 hormone in our bodies.
Tirzepatide is a dual-acting glucagon-like peptide-1 (GLP-1) receptor agonist and glucose-dependent insulinotropic polypeptide (GIP) and binds to both GLP-1 receptors and GIP.
Both semaglutide and tirzepatide are inject once a week, but dose is different. Semaglutide dosage is 2.4mg with initial dose 0.25mg. Tirzepatide dosage is 5mg,10mg or 15mg with initial dose 2.5mg.
